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Ferroptosis in chondrocytes is a key driver of cartilage degeneration, where iron overload induces cell death through lipid peroxidation, suppresses cartilage regeneration, and exacerbates OA progression (Simo and Cancela, 2021)

Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

Flavonoid classification As shown in Fig

Moreover, the concentration-dependent dual role of RSVacting as an antioxidant at low doses but exacerbating oxidative stress at higher concentrationsadds complexity to its therapeutic window and necessitates precise dosing strategies in co-delivery systems to avoid unintended cytotoxic effects [153]