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This includes structural alterations in glutamatergic neurons, as well as changes in mRNA and protein expression of molecules involved in glutamate signaling (glutamate receptors, glutamate transporters, glutamate synthesizing enzymes, glutamate receptor co-agonists), although some inconsistencies have also been reported [30]

These include the regulation of various metabolic processes, including, amino acid metabolism, fatty acid metabolism, the production of cofactors or vitamins, the excretion of digestive enzymes, the production of several antagonistic molecules, the improvement of immune functions, stress mitigation, the disruption of quorum-sensing molecular mechanisms, and the detoxification of heavy metals (Linda et al., 2025)

3C, it is evident that the absorption peak at 412 nm in the control group and ZIF8 treated solution is significantly stronger than in the GSH solution after the addition of CZ nanoparticles, suggesting a noticeable reduction in GSH concentration