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Borrego-Ruiz and Borrego, 2024)

Primitive hematopoietic progenitor cells were enriched from the BM using the Mouse Lineage Cell Depletion Kit (Miltenyi Biotec Inc., Auburn, CA)

Hyperglycemia, increased sorbitol and protein kinase C, elevated homocysteine, reduced nitric oxide and excessive Reactive Oxygen Species (ROS) damage endothelial tissue and produce a rheological change that increases vascular resistance and reduces blood flow to the nerve 3.3 Risk factors Diabetes is the strongest risk factor for DPN, along with certain disease characteristics such as diabetes duration and poor glycemic control in terms of fasting blood glucose (FBG), glycated hemoglobin (HbA1c

Demonstrates seizure-modulating effects in rodent metaphit-provoked seizure assays, useful for neuroexcitation research