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Description

Nicotinamide analogs such as 6-methylaminonicotinamide form one class of NNMT inhibitors that work by mimicking the natural substrate, NAM, and competing for the enzymes active site 197

325 ACC activity is increased in the brains of AD mice

Eur J Endocrinol (2012) 167:65162

Exp Neurol 179:3846 [DOI] [PubMed] [Google Scholar] 61.Vila M, Laguna A, Carballo-Carbajal I (2019) Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology