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395,396 A phase Ib/IIa study of synergistic therapy of pancreatic adenocarcinoma with Atu027 and gemcitabine showed this therapy for pancreatic carcinoma was safe and well-tolerated

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Intracellular ROS are believed to be mainly produced by the mitochondria and NADPH oxidase (NOX) and can be associated with various physiological processes, such as proliferation, cell signaling, and oxygen homeostasis