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The objective is not to take so much metformin as to induce a hypoglycemic state

Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

& Yang, Y.-Y

In fact, the promise of such strategies in revealing hidden features of cellular response to metal complexes with potential anti-cancer action has been recently reviewed, giving particular emphasis to NMR as the chosen analytical technique (32)