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10.1016/j.chembiol.2016.12.007 23 KerinsM

By 8 weeks, M B cells frequency dropped significantly, indicating that Gclc -deficient T1 B cells limit M B cells development and that Gclc is crucial for the transition from T1 to T2 B cells

This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis