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Fusion of the mitochondrial outer membrane involves an irreversible GTPase-driven fusion reaction, primarily based on homotypic or heterotypic oligomeric complexes of Mfn1 and Mfn2, and proceeds through docking, tethering, and elongation steps to achieve contact with the mitochondrial outer membrane (Song et al., 2009)

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This early finding suggests that it is eliminated from the body fairly rapidly, and probably does not pose too much of a risk of building up to dangerous levels if taken for extended periods nonetheless, more studies in human users will be needed to know for sure, so this should not be considered a definitive finding until more research is done

These high doses, given as a single bolus, may worsen clinical status and are no longer recommended