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Ethical approval The animal experiments and procedures were performed in accordance with national guidelines for the use and care of laboratory animals, and the study was approved by Ataturk University's local animal care committee (approval number: 2014-1/12)

Beta-tubulin was used as an internal control (Invitrogen, MA5-16308, 1:5,000)

Many point sources of pollution, such as mining, textile industries, chemicals manufacturing and formulating facilities, food processing, and pharmaceutical production discharge waste containing water into lotic ecosystems in Sri Lanka