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Copper induces oxidative stress and apoptosis in the mouse liver

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Oral citicoline (1,600 mg/day) was given for 60 days followed by 60 days of washout, and the therapeutic cycle was repeated once

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Vectorial flow replaces the old free diffusion view, as ROS are generated at membranes or enzyme clusters and then channeled along protein networks, redox relays and contact sites (e.g., MAMs) to reach defined effectors

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