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Knowledge Gaps and Scholarly Debates USP37 as an Alternative Target: Recent discovery of the CHK2-USP37-FOXO4 stability axis suggests that small-molecule inhibitors of USP37 (e.g., Dacarbazine) may offer a more pharmacologically drug-like route to achieving the same senolytic effect as the FOXO4-DRI peptide (PNAS, 2026)

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Urokinase is an activator for matrix remodeling and is detectable in tissues suffering wound healing and liver regeneration