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Without this offset, both compounds compete for limited NAD+ and receptor access simultaneously, creating a metabolic bottleneck that reduces efficacy of both

JDD 19, 713720

Chloroquine sensitises hypoxic colorectal cancer cells to ROS-mediated cell death via structural disruption of pyruvate dehydrogenase kinase 1

It also "recharges" other important antioxidants, such as vitamins C and E, and CoQ10, giving them the ability to continue fighting free radicals for extended periods of time