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Viehbacher, President and Chief Executive Officer of Biogen We will work alongside Eisai to engage the medical community and support the patient journey, especially early diagnosis, as mounting evidence suggests early intervention may provide greater impact on disease progression. Eisai will conduct a post-marketing special use results survey in all patients who are administered LEQEMBI (all-case surveillance) until data from a certain number of patients are accumulated, in accordance with an approval condition imposed by the Ministry of Health, Labour and Welfare

Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting

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Elford JD, Becht N, Garssen J, Kraneveld AD, Perez-Pardo P