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AGEs not only react with biomolecules such as proteins and lipids but also exacerbate oxidative stress, impairing the energy metabolism of cardiomyocytes and ultimately leading to cardiac dysfunction (84)

The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes

Figure 2 NF1, PTEN, and TSC1/TSC2 act as negative regulators of mTOR complex 1 (mTORC1), of which single gene mutations lead to enhanced mTOR activity in the brain in various mouse models (60, 62, 65)

Tremendous evidence suggests that the tumor has evolved at least three mechanisms to avoid ferroptosis, such as downregulating PUFA-PL levels and lipid peroxidation, astricting the storage of iron in LIP, and uprising defense systems against ferroptosis