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288-290 Given the absence of untreated controls, randomized designs, and/or placebo control groups, the studies cannot be interpreted because of the inability to account for change over time in disease state independent of treatment

To examine the role of ASGPR in efficacy of various liposome formulations, wildtype and ASGPR knockout mice were administered MC3 liposomes containing the AD-1661 siRNA composition, at 3, 1, and 0.3 mg/kg as described in Example 1

Cascade POD-CAT mimics Mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) exhibit POD and CAT-mimetic activities, facilitating ROS removal via cascade reactions

Martirosyan, et al