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One reason may be that bile acid production declines with age, leading to greater concentration of cholesterol in bile (Pak 2016)

Naheed, et al., Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomized controlled trial, The Lancet 366 , 9991004 (2005)

Single MnTCPP + only presents insignificant SOD-like activity (Supplementary Fig

In -cells, these are mainly superoxide (O 2 ) and other oxidizing byproducts generated in mitochondria, reduced flavoprotein oxidases or monooxygenases and NADPH oxidase (NOX) family