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Description

Therefore, we focused on OLFM4 for subsequent investigation

Jarrold (Hudgins et al., 1999

Nutritienda:

The intra-molecular hydrogen bonds between R68/E37, and Y71/D54 are also seen in the inactive WT-HRAS GDP structure (PDB code: 4Q21) 32 , suggesting K3 binding locks KRAS in an inactive conformation by stapling the switch regions together through induced hydrogen bonding, reducing conformational dynamics required for its activity