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Identification as a Hageman factor cleaving enzyme

A systematic division of different strategies to target -syn thus separates stabilizing the physiological conformation of -syn, decreasing its expression, inhibiting its aggregation, and increasing intracellular clearance, from transmission-directed approaches including inhibiting uptake by neighboring cells and enhancing extracellular clearance mechanisms (Figure 2

hCiPSC treatment partially reversed this dysbiotic state, reducing the abundance of Pseudomonadota and Deferribacterota and promoting the recovery of Bacteroidota and Verrucomicrobiota

Therefore, lactate metabolism is undeniably important in TC