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(13), the subcutaneous implantation of E2 silicone capsules demonstrated that supplementation with low concentrations of E2 (30 mg/mL) significantly diminished the apnea reflex induced by CIH in OVX rats, as well as the afferent response to chemical stimuli and the pulmonary inflammatory response

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In lung cancer cells, EGLN1 and c-Myc are recruited to the promoter of lymphoid-specific helicase (LSH) at two hypoxia inducible factor-1 (HIF-1) binding sites, which directly facilitates the expression of LSH by inhibiting HIF-1[115]

In line with the postnatal TGF-1 expression worsening ASD-like symptoms in mice, TGF-1 and IL-9 exacerbated excitotoxic brain lesions through mast cells in mice [174]