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Thus, the heterozygous KEAP1 mutation conferring the growth advantage on cancers is consistent with the two-site binding model and hinge and latch model of the Keap1Nrf2 system

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Long-term stress dysregulates typical hormone response patterns by causing continuous hormone secretion, which affects metabolism and contributes to mental and physical health disorders 40

Data availability Boxplot data of differential gene expression in tumor and normal tissues were obtained from TNMplot ( All data are available in the article and the supplementary information, and from the corresponding authors upon reasonable request