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Oncol 36 , 19942001 (2018)

The use of an optimised internal standard minimises any analytical variations that could be crucial when calculating the GSSG/GSH ratio

3.3 Mechanical stress and ECM remodeling Throughout the initiation and progression of pulmonary fibrosis, mechanical stressan essential exogenous biophysical cueis regarded as a pivotal regulator of epithelial-to-mesenchymal transition (EMT) and fibrotic tissue expansion ( Experimental data demonstrate that sustained mechanical stretch activates the TGF-/Smad axis, suppresses E-cadherin, and elevates mesenchymal markers such as Vimentin and Snail, thereby driving alveolar epithelial cells toward a mesenchymal phenotype