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Beyond its energy role, NAD+ is the essential substrate of sirtuins (SIRT1-SIRT7), deacetylases that regulate mitochondrial biogenesis, DNA repair, and resistance to cellular stress (Imai & Guarente, Trends Cell Biol 2014)

A placebo-controlled clinical trial demonstrated that a peptide serum containing SNAP-8 led to a significant reduction in expression lines and overall improvement in skin texture

However, the clinical utility of current antifungal therapies is hindered by challenges such as the emergence of drug resistance, limited antifungal spectra, and adverse side effects

For example, EVs from senescent cells are protein-rich in DPP4, which impedes the recruitment of EVs into proliferating cells [177] (Fig