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Immunohistochemistry confirmed arginase-1 in the lungs and macrophages in the BALF and demonstrated arginase-1 mRNA expression and p38 MAPK phosphorylation were inhibited in peritoneal macrophages stimulated with IL-4 [66]

doi: 10.1038/nature07383

The CGI-Improvement scale (CGI-I) was used to evaluate the degree of improvement in the patients symptoms relative to the baseline, and the CGI-Efficacy Index (CGI-EI) assessed the clinical efficacy of bumetanide by considering both the treatment effect and associated side effects

2006 Richards F, Cooper MR, Pearce LA, Cowan RJ, Spurr CL: Familial spinocerebellar degeneration, hemolytic anemia, and glutathione deficiency