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Dihexa is studied in models involving hepatocyte growth factor pathway activity, synaptogenesis, neuroplasticity-associated mechanisms, memory-related biology, and central nervous system signaling

The pyrophosphate produced was measured and quantified and then converted to cyclic-di-GMP production rate (two molecules of pyrophosphate equals to one molecule of cyclic-di-GMP)

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In old female Sprague-Dawley rats, curcumin treatment decreased the rate of A deposition and despite receiving an intracerebroventricular infusion of A , both pre- and post-synaptic protein levels increased by orally administrating 500 ppm curcumin for 2 months prior to A infusion