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In contrast, GDNF mimetics and blood-brain barrier-penetrating CDNF peptides offer the advantages of both targeting and delivery efficiency, with preliminary preclinical or clinical data accumulated, providing a more translationally promising solution to the delivery challenges of NTFs-based therapies

MTF2 from WT mESCs was eluted as a broad peak, likely corresponding to a mixture of the monomeric and dimeric forms of MTF2-containing PRC2.1 (Fig

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