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Ceramides - Lipotoxic Inducers of Metabolic Disorders

Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan

Gln is predominantly synthesized from l-glutamate (Glu) and ammonia (NH 3 ) by the action of the largely cytosolic enzyme Gln synthetase (GS), whereas the mitochondrial enzyme glutaminase (GLS) is responsible for the hydrolysis of Gln to Glu and NH 3