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Topical administration of natural antioxidants, such as quercetin and epigallocatechin gallate (EGCG), is capable of promoting a significant reduction in lipid peroxidation, evidenced by a reduction of approximately 35% in MDA levels, as well as increasing the activity of endogenous antioxidant enzymes, such as SOD and CAT, in the affected skin tissue [59]

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The blockage of VEGF/VEGFRs interaction led to the inhibition of angiogenesis and tumor growth