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In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation

~2-6 hours (estimated, polypeptide complex) Varies by component (~1-6 hours) ~0.5-2 hours (estimated, tetrapeptide) ~0.5-2 hours (estimated, ultrashort peptide) ~3-4 hours (estimated, based on peptide clearance kinetics) 2.5-3.5 hours (subcutaneous/IV) ~30-45 min IV plasma (functional effects persist 2-4 hours via SubQ absorption) ~2-4 hours (estimated) ~3 min (IV), central effects last 2-4 hours (intranasal) ~2-4 hours (estimated, D-retro-inverso form may extend effective duration) ~2-4 hours (estimated) ~2-4 hours (estimated from in vitro decay

The novel and enigmatic nature of this yet-to-unfold pathology demands extensive research seeking answers for both the molecular underpinnings and potential therapeutic targets