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Recently, it has gained attention for its potential skin-lightening properties, specifically in reducing hyperpigmentation and dark spots

Argireline Acetyl Hexapeptide-3 (aka Acetyl Hexapeptide-8) is most commonly known by the brand name Argireline (trade name of the Spanish cosmetics firm Lipotec) [3]

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In practice, simultaneous application is problematic: a 2022 Journal of Cosmetic Dermatology study found that applying both at the same time increased transepidermal water loss by 41% and produced 3.2 times more self-reported stinging compared to staggered application