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Therapeutic targeting of proteostasis in NDDs NDDs are unified by the progressive accumulation of misfolded and aggregation-prone proteins, chronic cellular stress, and selective neuronal vulnerability

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Importantly, a recent study revealed that xCT suppression acts synergistically with the immunotherapeutic agent anti-CTLA-4 150

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4 Electron micrographs reveal progressive pathological alterations of the podocytes in Pod R231Q/A286V mice

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10.1100/2011/172893 [DOI] [PMC free article] [PubMed] [Google Scholar] Porsolt R

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