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Abstract Acetaminophen (APAP)-induced acute liver injury (AILI) is primarily driven by CYP3A4mediated overproduction of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), CYP3A4 activity serves as the rate-limiting determinant of NAPQI accumulation levels

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doi: 10.1002/cbf.1025 [DOI] [PubMed] [Google Scholar] 16.Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, et al

There are four subtypes of bipolar disorder that are categorised based on the occurrence, duration, and intensity of manic and depressive episodes [2]