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Measures to be taken in case of overdose Symptoms: no cases of overdose have been reported

If weight loss has plateaued or side effects are limiting progress, your clinician can evaluate whether a dosing adjustment or broader treatment plan modification is appropriate

Leukemic cellular retinoic acid resistance and missense mutations in the PML-RARa fusion gene after relapse of acute promyelocytic leukemia from treatment with all- trans retinoic acid and intensive chemotherapy