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1, 25 Sept

In general, stabilization of HIF and an increase in its hyper-inflammatory activity occur with loss or dysfunctional protective action of the cellular Sirtuins

Moreover, according to this model GluN1-S773 might be interacting with two EAR-20 residues, Glutamine 9 (Gln 9) and Glutamate 7 (Glu 7) by means of 4 different hydrogen bonds