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Furthermore, while the N-terminal self-cleaving reaction was very inefficient for these split inteins, the C-terminal cleaving reaction occurred even when the five native flanking C-extein amino acids were absent

Research demonstrates that TB-500 administration mobilizes EPCs from bone marrow reservoirs, with animal studies showing 3-fold increases in circulating EPC numbers that contribute to neovascularization through both structural incorporation into developing vessels and paracrine secretion of pro-angiogenic factors

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10.1007/s11033-022-07468-0 13 GhareghomiS.Moosavi-MovahediF.SasoL.Habibi-RezaeiM.KhatibiA.HongJ.et al (2023)