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A later time point (1542 days (median 20, mean 22.7)) after completion of phage therapy found decreased PsA CFU median 7.8 10 5 (2.0 10 4 , 2.7 10 7 ) or mean 1.1 10 7 ( 7.5 10 6 s.e.m.) CFU ml 1 , which is a 10 3 median, or 10 1 mean difference, respectively ( P = 0.0112, two-way ANOVA with Dunnetts multiple-comparisons test)

All statistical analyses were conducted in the R programming language (version R 3.4.0 for Windows) using packages lme4 (1.113), lmtest (0.935) and multcomp (1.46) 90,91,92

Each softgel provides 400mg of berberine hydrochloride, with two softgels giving 800mg daily