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Imaging biomarkers Neuroimaging techniques, particularly magnetic resonance imaging (MRI), represent a non-invasive, in vivo method for assessing iron deposition in the brain and can serve as an indirect means of evaluating ferroptosis risk

2.1.2 The role of Cys93 in counteracting tissue hypoxia Among the conserved amino acids in hemoglobin, the cysteine at position 93 on the -globin chain (Cys93) plays a key role in the physiological response to low oxygen availability ( During hypoxic stress, hemoglobin undergoes a conformational shift that exposes Cys93, allowing SNO-hemoglobin (SNO-Hb) to form

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