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5.3 Disease-specific determinants of perinatal glucocorticoid sensitivity Multiple perinatal complications have been associated with fetal/neonatal dysregulation of the HPA axis, cortisol metabolism, and tissue GR expression and function ( Table 3 )

The same report estimates that 252 million adults are living with undiagnosed diabetes, 2 and diabetes was responsible for over 3.4 million deaths in 2024

1) are largely based on the WCRF/AICR systematic reviews and Continuous Update Project reports, with additional evidence from systematic reviews and large pooled analyses published since the most recent WCRF/AICR reports

Surgical treatment is foreseen for a selected group of patients (e.g., limited disease and eligible for platinum therapy) and a remaining matter of debate