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doi: 10.1080/00218839.2008.11101443 67

Enamel matrix peptides like P11-4 show radiographic remineralization changes within 36 months

Depending on various factors including the patients age and overall health, combined with the exact condition being treated, a series of up to 4-5 injections may be required, although one can typically expect to see measurable progress with each injection

When metabolic stress occurs, MOTS-c in cells can be transferred to the nucleus in an AMPK-dependent manner and bind to transcription factors regulated by ARE, thus improving the stress resistance of cells (16, 24)