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One of the main differences of the aforementioned study and our model is the utilized cell type

Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)

TCDD targeted the aryl hydrocarbon receptor in the intermembrane space of organelles in mitochondria (miAhR), leading to degradation of miAhR and dysfunction of mitochondria, which clinically manifested as metabolic dysfunction, e.g