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The compound also shows no inhibitory activity against nicotinamide phosphoribosyltransferase (NAMPT) or sirtuin 1 (SIRT1), key enzymes in the NAD+ salvage pathway

Published work has described 5-Amino-1MQ as a selective, cell-permeable small-molecule NNMT inhibitor and has used it in controlled models to study enzyme inhibition, metabolic pathway changes, and related cellular responses

Med Gas Res 2:9 Avtan SM, Kaya M, Orhan N, Arslan A, Arican N, Toklu AS, Grses C, Elmas I, Kucuk M, Ahishali B (2011) The effects of hyperbaric oxygen therapy on blood-brain barrier permeability in septic rats

Athanasios Jamurtas, University of Thessaly, Greece