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Within the realm of bone tissue engineering, this microenvironment comprises both osteogenic and immune cell lineages, including mesenchymal stem cells (MSCs) and pre-osteoblasts as the principal osteogenic cells, and macrophages as the dominant immune cells ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering

Ben-Horin S, Salomon N, Karampekos G, Viazis N, Lahat A, Ungar B

Abstract Extracellular vesicles (EVs) are known to mediate cell communications and shape tumor microenvironment

Glutathione-S-transferase (GST) is a highly soluble and stable 26 kDa enzyme that catalyzes the protective mechanisms of Glutathione (GSH)