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Gabernet L, Pauly-Evers M, Schwerdel C, Lentz M, Bluethmann H, Vogt K, Alberati D, Mohler H, Boison D (2005) Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

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Similar to ME/CFS patients, the TRPM3 dysfunction in natural killer cells also existed in Long Covid patients but not in healthy controls.[ref] A study involving cells from long Covid patients who were taking LDN showed that the LDN restored TRPM3 ion channel function.[ref] Naltrexone metabolism: The rate at which a drug is broken down (metabolized) affects how long it stays in your system