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Finally, the methods relying on remote directing effect of groups attached to the indole nitrogen, such as the copper-catalyzed C6 functionalization of indoles using the phosphinimide directing group 55 , were not examined, as (1) the deprotection step involves harsh reduction conditions (e.g., LiAlH 4 ) incompatible with MGs functionalities or (2) the C6 functionalization is too restrictive in terms of the functionalization chemistry or substrate requirements 56,57

It also supports collagen and reticulin formation and is anti-inflammatory

1,2 While the prevalence of WD is reported to range between 0.25 and 4.00 per 10,000 people, the potential incidence is much higher