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In conclusion, there is a feed-forward mechanism in the cells whereby translation of nucleus-encoded mitochondria-related mRNAs is regulated via mTORC1/4E-BP pathway to induce mitochondrial ATP production capacity and thus provide sufficient energy for protein synthesis (100)

Cost-saving by using less imidazole During purification of His-tagged proteins with conventional Ni-NTA and Ni-IDA based affinity resins, imidazole is generally required to include in the binding and wash buffers to modulate non-specific binding

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

DN is pathologically characterized by mesangial matrix thickening, progressive destruction of glomerular and tubulointerstitial, and loss of functioning glomeruli, ultimately leading to chronic renal failure [138, 139]