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Second, being a potent antioxidant, NAC may exert direct effects on some reactive oxygen species (ROS), whereas it is a precursor of cysteine (an essential substrate for glutathione synthesis) and also regulates the redox state by maintaining the thiol pool [20]

Further studies documented that NTBC was a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPD), which catalyzes conversion of 4-hydroxyphenylpyruvate to homogentisic acid 53 (Figure 1)

Ogu UO, Thomas M, Chan F, Vattappally L, Sebastian G, Crouch A, You S, Minniti CP (2021) L-glutamine use in adults with sickle cell disease: clinical trials where success meets reality

Control of p53 and NF-B signaling by WIP1 and MIF: role in cellular senescence and organismal aging