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10.1172/JCI116842 22 MarticI.Jansen-DrrP.CavinatoM

Autophagy is a natural, regulated PCD behavior

Several groups have independently developed compounds that bind this pocket with varying affinities and efficacies, predominately in the micromolar range 5-8 , except for BI-2852 which has nanomolar binding affinity and efficacy 11

On the other hand, low-dose anti-VEGFR2 treatment normalized tumor vessels with increased pericyte coverage, improved tumor perfusion, and eventually promoted the infiltration of CD8 + and CD4 + T cells into the tumor