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J Trop Life Sci 13:369376

Nucleic-acid-based carriers, in turn, suffer from instability and rapid systemic clearance, and may provoke unintended immune responses [279]

Nanobiotechnology 23 (1), 314

It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (99, 115, 125, 161, 162)