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10.1101/gad.276428.115 22 ChengH.YangZ

3.1.5 HIF-1 and HIF-2 HIF-1 and 2 are TFs, playing a significant role in proliferation, oxidative stress, inflammation, and apoptosis, by binding to its hypoxia response elements (HRE) on the promoter region of its target genes under hypoxic or toxic conditions ( 3.1.6 NF-B NF-B, a master regulator of genes involved in cytokine production and cell survival, plays an important role in Mn-induced neurotoxicity (for review, see Pajarillo et al., 2021)

Genetic variants in the AOC1 gene (encoding the DAO enzyme) and the HNMT gene are the primary genetic factors

Cordeiro S, Silva B, Martins AM, Ribeiro HM, Gonalves L, Marto J