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In addition, current research on saponin-chemotherapeutic combination therapies remains fragmented, with inconsistent research focuses across different saponins and chemotherapeutic agents, and a lack of systematic exploration into their synergistic mechanisms

Existing studies predominantly use cyclophosphamide to establish non-tumor-bearing immunocompromised mouse models, and only verify the restorative effects of saponins on immune organs, immune cells, and cytokine production [114,115,116]

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synoviae affects ciliary motility in the oviduct (Figure 2G) which may induce changes in the uterine fluid content thereby affecting the deposition of calcium carbonate crystals [6, 36]