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Histone deacetylase function was impaired, and a decrease in major histocompatibility complex class II was observed, suggesting that ZIP14-mediated Zn transport may impact gut barrier function by epigenetic mechanisms (139, 140)

If these values have dropped to standard level it is only an indication that treatment is effective and should not be used to measure treatment efficacy (values are good, lets stop treatment)

Therefore, the use of supplements, such as vitamin B12 drops, is typically more than enough if taken as needed, to increase levels naturally, and have vitamin B12 levels increase naturally

According to NICE, the prevalence of vitamin B12 deficiency is about 6 percent in people below the age of 60 years and 20 percent among those 60 years and older